La Roche-Posay Hyalu B5 Suractivated Serum

Serum~$40typical, July 2026

Our read, in one look

Glycerin is the reason to consider this serum, with Pro-vitamin B5 behind it.

The case for it

  • Glycerin, strong evidence for hydration
  • Pro-vitamin B5, strong evidence for the barrier
  • No parabens

Mind this

  • Morning or evening, whichever suits your routine
  • Add it on its own for a week or two, so you know what your skin is answering to
Best for dry, dehydrated, sensitive, compromised barrier skinFind it on amazon.com
Maya's read

La Roche-Posay Hyalu B5 Suractivated Serum is a serum built around Glycerin, Pro-vitamin B5 and Hyaluronic acid. It leans strongest on hydration, barrier repair, anti-aging. Best suited to dry, dehydrated and sensitive skin. Worth noting it contains fragrance, so reactive skin should patch-test.

Skip it if your skin reacts to fragrance: this one is scented.

The formula, drawn

Every ingredient in label order, coloured by the job it does here.

26 of the 32 sit above the 1% line. The other 6, hatched, are each under 1%. Widths show the ORDER on the label and nothing else: the label never discloses amounts, so we never draw them.

  • Actives & signals
  • Hydrators
  • Texture & base
  • Preservation
  • Not in our library yet

What it delivers

Hydration10
Barrier repair8
Brightening / tone3
Oil-control & blemishes3
Anti-aging7

How it feels A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. (estimated from the formula)

What's in it that matters

The molecule doing the workGlycerinHumectant · strong evidence

Classic humectant with strong evidence for improving skin hydration and supporting barrier when combined with emollients.

  • Pro-vitamin B5Supporting Activestrong evidence

    Humectant and soothing ingredient that helps calm irritation and supports barrier repair and recovery.

  • Hyaluronic acidHumectantstrong evidence

    Water-binding molecule that increases hydration; works best under occlusive/emollient layers to reduce evaporation.

  • MadecassosideSupporting Activemoderate evidence

    Purified centella triterpene that calms inflammation supports barrier repair and enhances collagen and elastic fiber remodeling in photoaged skin.

  • AdenosineActive|Supporting Activemoderate evidence

    Signal nucleoside that modestly improves periorbital and facial wrinkles and elasticity in Korean cosmetic studies with good tolerability.

  • Hydrolyzed hyaluronic acidHumectantmoderate evidence

    Hyaluronic acid cut into shorter fragments, so it sits into the surface rather than resting on top of it. It works with the full-size form rather than replacing it.

How to use it

Morning and/or night, after your thinner water-based steps and before heavier creams.

Where it acts

The same cross-section as our 500 dalton page, with this formula's actives on the layer each one works on. Depth is the anatomy's, never an ingredient's.

4 of this product's actives have a layer we can defend. 2 did not, so they are not on the diagram: no source and no honest derivation means no dot.

Against the average serum

HydrationBarrier repairBrighteningOil-controlAnti-aging
This productMedian serum (17 in catalogue)

It scores lower than the median serum on brightening.

On hydration, barrier repair, oil control and anti-aging it is level with the median, so that is not what sets it apart.

A median, not an average: one unusual formula should not move the middle. The numbers are the same 0 to 10 reads the comparison pages use.

The full ingredients list, decoded

Every ingredient on the label, in the order it appears (highest amount first). We link the 20 our library knows, name what each one does, and flag anything that can irritate or clog. The rest we leave plain, nothing is hidden.

All 32 ingredients, decoded
  1. Aqua/Water/EauSolvent (base)
  2. GlycerinHumectant
  3. can irritate
  4. mild irritant
  5. PanthenolHumectant
  6. DimethiconeOcclusive
  7. PEG-6 Caprylic/Capric GlyceridesEmulsifier
  8. Alpinia Galanga Leaf ExtractBotanical extract
  9. Calcium Chloride
  10. Glyceryl IsostearateEmollient (ester)
  11. PPG-6-Decyltetradeceth-30
  12. Sodium Acetylated Hyaluronate
  13. Algin
  14. AdenosineNucleoside
  15. Ammonium Polyacryloyldimethyl Taurate
  16. PropanediolHumectant
  17. HydroxyacetophenonePreservative
  18. Caprylyl GlycolPreservative booster
  19. Citric AcidExfoliant
    mild irritant
  20. Trisodium Ethylenediamine DisuccinateChelator (stabiliser)
  21. Acetyl Glucosamine
  22. roughly the 1% lineThe rules only require descending order above 1%. From Xanthan Gum down, these 6 can be listed in any order the brand likes, so position stops telling you anything.
  23. Xanthan GumThickener
  24. 1,2-HexanediolPreservative booster
  25. TocopherolAntioxidant
    mild irritant
  26. PhenoxyethanolPreservative
    mild irritant
  27. can irritate
Copy the raw INCI list

Aqua/Water/Eau, Glycerin, Alcohol Denat, Propylene Glycol, Panthenol, Pentylene Glycol, Dimethicone, PEG-6 Caprylic/Capric Glycerides, Alpinia Galanga Leaf Extract, Calcium Chloride, Glyceryl Isostearate, Madecassoside, PPG-6-Decyltetradeceth-30, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Algin, Adenosine, Ammonium Polyacryloyldimethyl Taurate, Propanediol, Hydrolyzed Hyaluronic Acid, Hydroxyacetophenone, Caprylic/Capric Triglyceride, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Glucosamine, Xanthan Gum, Butylene Glycol, 1,2-Hexanediol, Tocopherol, Phenoxyethanol, Parfum/Fragrance

Read enough? Find it on amazon.com

We don't make or sell skincare of our own. So there's nothing here we're trying to push, just an honest read of whether this formula suits your skin.

Compare it with…

All 15 comparisons

Common questions

Is La Roche-Posay Hyalu B5 Suractivated Serum good for dry skin?

By our read of the formula, it suits dry, dehydrated, sensitive skin. La Roche-Posay Hyalu B5 Suractivated Serum is a serum built around Glycerin, Pro-vitamin B5 and Hyaluronic acid. It leans strongest on hydration, barrier repair, anti-aging. Best suited to dry, dehydrated and sensitive skin. Worth noting it contains fragrance, so reactive skin should patch-test.

How do you use La Roche-Posay Hyalu B5 Suractivated Serum?

Morning and/or night, after your thinner water-based steps and before heavier creams.

What are the key ingredients in La Roche-Posay Hyalu B5 Suractivated Serum?

The actives that do the work are Glycerin, Pro-vitamin B5, Hyaluronic acid, Madecassoside, Adenosine, Hydrolyzed hyaluronic acid. The rest of the list is texture, preservatives and emulsifiers that hold the formula together.

What the 3D scene shows

The scene shows La Roche-Posay Hyalu B5 Suractivated Serum beside a cross-section of skin, with 2 of its ingredients drawn at the layer each one acts on and at one shared molecular scale: Glycerin and Pro-vitamin B5 in the stratum corneum, the dead outer layer where most skincare works. Depths come from the same sourced layer data as the rest of this site, and any ingredient whose layer is not established is left out rather than guessed.

Chemical structure of Glycerin
Building the scene…

This is skin, in section.

The molecules floating inside it are from this bottle, each at the layer it works on, drawn to one true scale. Drag to turn, pinch or scroll to zoom, tap a molecule for its evidence.

Skin in section· molecules from this formula · one true scale
tap it to decode ↻
Hyalu B5 Suractivated SerumLa Roche-Posay · Serum · ~$40

Glycerin is the reason to consider this serum, with Pro-vitamin B5 behind it.

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