Ingredient glossary

Syn-Ake

What Syn-Ake does for your skin, who it suits, and what to watch for.

INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate

Promising, not proven

In short: Syn-Ake delivers anti-aging support and wrinkle smoothing, suits most skin types, and the evidence behind it is emerging.

What it does
Anti aging, wrinkle smoothing
Best for
Most skin types
Evidence
Emerging
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The molecule

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The Glow take

Nice to have, and nothing to overthink.

Syn-Ake plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.

— Maya

What it does

  • anti aging
  • wrinkle smoothing

emerging evidenceA double blind placebo controlled study put twenty nine women on the peptide against thirty on placebo for twenty eight days and reported smoother skin on most of them. The manufacturer ran it and no independent trial has followed.

On a label: usually effective at 1-4%.

Who it's for, and who should skip it

Tends to suit

  • normal
  • combo
  • photoaged

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow

How it fits each skin type

  • DrySuits
  • CombinationSuits
  • OilySuits
  • SensitiveSuits

Often chosen for photoaged.

Where it fits in your routine

WhenMorning or evening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

  • other peptides
  • humectants

Syn-Ake, answered

Is Syn-Ake safe during pregnancy?

Yes. Syn-Ake is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Syn-Ake?

No specific group is flagged to avoid Syn-Ake. It is well tolerated by most skin. Still, introduce anything new one product at a time.

What concentration of Syn-Ake actually works?

Syn-Ake tends to do its job in the 1 to 4% range. Much lower and it is likely underdosed.

This, for every label you own

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Sources & how we reviewed this

Last reviewed August 2026. Educational information about a cosmetic ingredient, not medical advice.