Ingredient comparison

Retinyl Retinoate vs Syn-Ake: which one is right for your skin?

Same comparison whichever way you searched it: Syn-Ake vs Retinyl Retinoate.

Short answer: Retinyl Retinoate does more of the heavy lifting, while Syn-Ake is the gentler, lighter option. Pick the one that matches your skin.

Chemical structure of Retinyl Retinoate (Retinyl Retinoate)Retinyl RetinoatePromising, not proven
Chemical structure of Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate)Syn-AkePromising, not proven
8
Efficacy
5
2
Hydration
0
-1
Barrier
1
4
Brightening
0
3
Acne
0
8
Anti-aging
5
Retinyl Retinoate versus Syn-Ake, compared
ComparedRetinyl RetinoateSyn-Ake
PotencyHigherLower
Evidenceemerging evidenceemerging evidence
Irritation riskModerateLow
Clogs poresLowLow
In pregnancyNot in pregnancyConsidered safe
On a labelworks best above 0.05%usually effective at 1-4%

So which should you pick?

Choose Retinyl Retinoate if

  • fine lines and firmness are your main goal

Choose Syn-Ake if

  • your skin is sensitive or reacts easily
  • you are pregnant or breastfeeding, since only Syn-Ake is considered safe

The honest bottom line: Retinyl Retinoate does more of the heavy lifting, while Syn-Ake is the gentler, lighter option. Pick the one that matches your skin.

Pregnancy: Only Syn-Ake is considered safe to use in pregnancy.

Better for your concern

  • Fine lines and firmnessRetinyl Retinoate
  • Sensitive, reactive skinSyn-Ake

Based on their scores in the knowledge base. "Either" means both hold their own for that goal.

No known clash between these two. If you want both, you can layer them; introduce one at a time.

Check these two in the tool →Or decode a whole product label →

From our dataNeither has to be the answer: 49 other ingredients in our glossary share a family with these two.

Retinyl Retinoate vs Syn-Ake, answered

Which is stronger, Retinyl Retinoate or Syn-Ake?

Retinyl Retinoate is the more potent of the two, with the higher efficacy score. Syn-Ake is the lighter option.

Is Retinyl Retinoate or Syn-Ake better for sensitive skin?

Syn-Ake is the gentler choice for sensitive, reactive skin (low irritation risk, versus moderate for Retinyl Retinoate).

Can you use Retinyl Retinoate and Syn-Ake together?

There is no known clash between them. You can layer them if you like, just introduce one at a time.

General guidance, not medical advice. Read the full pages on Retinyl Retinoate and Syn-Ake.