Ingredient glossary

Adapalene

What Adapalene does for your skin, who it suits, and what to watch for.

INCI: Adapalene

Worth paying for

In short: Adapalene delivers anti acne and texture, suits oily skin best, and the evidence behind it is strong. One thing to know: not for pregnancy or breastfeeding; introduce it gently.

What it does
Anti acne, texture
Best for
Oily skin
Watch out
Not for pregnancy or breastfeeding; introduce it gently
Evidence
Strong
Does it clash with what you use? Check it →

The molecule

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Chemical structure of Adapalene (Adapalene)

The Glow take

One of the ingredients I trust most.

When your goal is calming breakouts and congestion, Adapalene delivers, and the research properly backs it up. Skip it while you are pregnant or breastfeeding, and the rest of the time bring it in slowly.

— Maya

What it does

  • anti acne
  • texture

strong evidenceRandomized trials show adapalene 0.1–0.3% is as effective or superior to low-strength tretinoin for acne with fewer local side effects.

On a label: works best above 0.1%.

Who it's for, and who should skip it

Tends to suit

  • acne prone
  • oily

Approach with care

  • pregnancy
  • breastfeeding
  • very sensitive
  • Clogs poresLow
  • Irritation riskModerate

How it fits each skin type

  • DryNeutral
  • CombinationNeutral
  • OilySuits
  • SensitiveTake care

Often chosen for acne prone. Take extra care if any of these apply to you: pregnancy, breastfeeding.

Where it fits in your routine

WhenEvening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

Adapalene, answered

Is Adapalene safe during pregnancy?

No. Adapalene is best avoided during pregnancy and breastfeeding. If you are pregnant or trying, leave this one out and ask your doctor about a safe alternative.

Who should avoid Adapalene?

Approach Adapalene with care if any of these apply to you: pregnancy, breastfeeding, and very sensitive. Its irritation risk is moderate, so introduce it slowly and patch test first.

What concentration of Adapalene actually works?

Research tends to show Adapalene starts pulling its weight above 0.1%. If a brand prints the percentage, that is the number to look for.

During pregnancy

Leave Adapalene out while you are pregnant or breastfeeding. It sits on the list of ingredients usually held back during this time.

When in doubt, check with your doctor or midwife. They outrank any website, including this one.

Commonly confused with

  • RetinolAdapalene is a prescription-grade retinoid built to be more stable and less irritating than the older ones.

This, for every label you own

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Sources & how we reviewed this

Last reviewed July 2026. Educational information about a cosmetic ingredient, not medical advice.