Ingredient pairing

Can you mix Adapalene and Vitamin B3?

Fine togetherThey're fine together.

AdapaleneVitamin B3

These two actually work well together, and are often formulated side by side.

Routine: You can use these together, morning or night.

AdapaleneWorth paying for
Acne10
Efficacy9
Anti-aging7

Skip if: pregnancy, breastfeeding, very sensitive

Not in pregnancy
Vitamin B3Worth paying for
Efficacy9
Barrier9
Acne8

Skip if: very sensitive in high

Which one goes first?

Apply Vitamin B3 first

  1. 1Cleanse
  2. 2Vitamin B3
  3. 3Adapalene
  4. 4Moisturize

On freshly cleansed skin, Vitamin B3 goes on first, then Adapalene over it. The rule of thumb is thinner and lower-pH first, richer last.

Adding Adapalene and Vitamin B3 to your routine

  1. Good news first: these two get along, so there is no special order or waiting period to manage.
  2. Still add them one at a time, a week or two apart, so if your skin does react you know which one to look at.

For your skin type Sensitive skin should ease in gently: Adapalene and Vitamin B3 can be mildly irritating on their own, and more so alongside another active.

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Adapalene and Vitamin B3, answered

Can you mix Adapalene and Vitamin B3?

They're fine together. These two actually work well together, and are often formulated side by side.

Should you use Adapalene and Vitamin B3 in the morning or at night?

Either. Adapalene and Vitamin B3 are fine to use together, morning or night.

How should you introduce Adapalene and Vitamin B3?

Good news first: these two get along, so there is no special order or waiting period to manage. Still add them one at a time, a week or two apart, so if your skin does react you know which one to look at.

What else should you not mix with Adapalene?

Adapalene is best kept apart from Salicylic acid (BHA), Lactic acid, Glycolic acid, Mandelic Acid. Introduce any new active one at a time.

Sources

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General guidance, not medical advice. When in doubt, introduce one product at a time.