Ingredient glossary

Methylisothiazolinone

What Methylisothiazolinone does for your skin, who it suits, and what to watch for.

INCI: Methylisothiazolinone · Also: MI

Quietly necessary

In short: Methylisothiazolinone delivers preservation, suits most skin types, and the evidence behind it is strong. One thing to know: can irritate, ease in slowly.

What it does
Preservation
Best for
Most skin types
Watch out
Can irritate, ease in slowly
Evidence
Strong
Does it clash with what you use? Check it →

The molecule

Tap to enlarge
Chemical structure of Methylisothiazolinone (Methylisothiazolinone)

The Glow take

Quiet, essential, and nothing to fear.

Methylisothiazolinone keeps a product safe to use from the first pump to the last, at tiny amounts. Not something you pay a premium for.

— Maya

What it does

  • preservation

strong evidenceEpidemiologic data from large patch-test series show methylisothiazolinone sensitization rates reaching six to seven percent with facial and hand dermatitis from cosmetics and paints prompting regulatory restriction.

Who it's for, and who should skip it

Tends to suit

  • all

Approach with care

  • very sensitive
  • eczema
  • formaldehyde allergy
  • Clogs poresLow
  • Irritation riskHigh

How it fits each skin type

  • DrySuits
  • CombinationSuits
  • OilySuits
  • SensitiveTake care

Take extra care if any of these apply to you: eczema, formaldehyde allergy.

Where it fits in your routine

WhenMorning or evening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

  • alternative preservatives

Methylisothiazolinone, answered

Is Methylisothiazolinone safe during pregnancy?

Yes. Methylisothiazolinone is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Methylisothiazolinone?

Approach Methylisothiazolinone with care if any of these apply to you: very sensitive, eczema, and formaldehyde allergy. Its irritation risk is high, so introduce it slowly and patch test first.

What concentration of Methylisothiazolinone actually works?

Its concentration is rarely printed on the label, so use the ingredient list as your clue: near the top third it is likely doing real work, near the bottom it is more of a sprinkle.

This, for every label you own

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Sources & how we reviewed this

Last reviewed July 2026. Educational information about a cosmetic ingredient, not medical advice.