Ingredient glossary

Ergothioneine

What Ergothioneine does for your skin, who it suits, and what to watch for.

INCI: Ergothioneine · Also: L-Ergothioneine

Decent support

In short: Ergothioneine delivers antioxidant and photoprotection, suits most skin types, and the evidence behind it is emerging.

What it does
Antioxidant, photoprotection
Best for
Most skin types
Evidence
Emerging
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The molecule

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Chemical structure of Ergothioneine (Ergothioneine)

The Glow take

Nice to have, and nothing to overthink.

Ergothioneine plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.

— Maya

What it does

  • antioxidant
  • photoprotection
  • repair

emerging evidenceCell and clinical poster data show topical ergothioneine reduces MMP-1 secretion and hydroxyl radicals more effectively than idebenone in photoaged skin but large independent trials are still lacking.

On a label: usually effective at 0.1-1%.

Who it's for, and who should skip it

Tends to suit

  • photoaged
  • normal
  • dry
  • combo

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow

How it fits each skin type

  • DrySuits
  • CombinationSuits
  • OilySuits
  • SensitiveSuits

Often chosen for photoaged.

Where it fits in your routine

WhenMorning
Where in the orderAfter cleansing, under your SPF

Plays well with

Ergothioneine, answered

Is Ergothioneine safe during pregnancy?

Yes. Ergothioneine is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Ergothioneine?

No specific group is flagged to avoid Ergothioneine. It is well tolerated by most skin. Still, introduce anything new one product at a time.

What concentration of Ergothioneine actually works?

Ergothioneine tends to do its job in the 0.1 to 1% range. Much lower and it is likely underdosed.

This, for every label you own

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Sources & how we reviewed this

Last reviewed July 2026. Educational information about a cosmetic ingredient, not medical advice.