Ingredient glossary

Acetyl Tetrapeptide-5

What Acetyl Tetrapeptide-5 does for your skin, who it suits, and what to watch for.

INCI: Acetyl Tetrapeptide-5 · Also: Eyeseryl

Promising, not proven

In short: Acetyl Tetrapeptide-5 delivers de puffing and firming, earns its place for periorbital puffiness and dark circles, and the evidence behind it is emerging.

What it does
De puffing, firming
Best for
Periorbital puffiness, dark circles
Evidence
Emerging
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The molecule

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Chemical structure of Acetyl Tetrapeptide-5 (Acetyl Tetrapeptide-5)

The Glow take

Nice to have, and nothing to overthink.

Acetyl Tetrapeptide-5 plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.

— Maya

What it does

  • de puffing
  • firming
  • dark circle support

emerging evidenceManufacturer and early clinical data report up to seventy percent reductions in periorbital edema over sixty days at around one percent though independent large-scale trials are still limited.

On a label: usually effective at 0.5-2%.

Who it's for, and who should skip it

Tends to suit

  • periorbital puffiness
  • dark circles
  • photoaged

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow

How it fits each skin type

  • DryNeutral
  • CombinationNeutral
  • OilyNeutral
  • SensitiveNeutral

Often chosen for periorbital puffiness, dark circles, photoaged.

Where it fits in your routine

WhenMorning or evening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

Acetyl Tetrapeptide-5, answered

Is Acetyl Tetrapeptide-5 safe during pregnancy?

Yes. Acetyl Tetrapeptide-5 is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Acetyl Tetrapeptide-5?

No specific group is flagged to avoid Acetyl Tetrapeptide-5. It is well tolerated by most skin. Still, introduce anything new one product at a time.

What concentration of Acetyl Tetrapeptide-5 actually works?

Acetyl Tetrapeptide-5 tends to do its job in the 0.5 to 2% range. Much lower and it is likely underdosed.

This, for every label you own

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Sources & how we reviewed this

Last reviewed July 2026. Educational information about a cosmetic ingredient, not medical advice.